Since there may be a number of relevant topic tags associated with any given article, it’s not possible to entirely block topics at this time.
Let’s say you follow the #Celebrity topic feed. An article about Kim Kardashian, from that topic, appears in your feed. If you select Less like this for #Kim Kardashian, but also follow #Los Angeles and #Kanye West topic feeds, it’s possible that you may still see articles about Kim Kardashian if the article has other topic tags associated with it.
Less like this is a signal that accumulates over time and combines with other signals (article views, likes, your followed topics) that affect the frequency of articles you see but may not eliminate the topic entirely from your feed.